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KMID : 0360320000320040817
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Journal of Korean Cancer Research Association
2000 Volume.32 No. 4 p.817 ~ p.821
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A Case of Triple-Alkylating Regimen and Peripheral Blood Stem Cell Transplantation for a Patient with Relapsed Ovarian Carcinoma
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1조석구/1Seok Goo Cho
1박진노/1홍영선/1김훈교/1이경식/1김춘추/2이준모/2남궁성은/1Jin No Park/1Young Sun hong/1Hoon Kyo Kim/1Kyung Shick Lee/1Chun Choo Kim/2Jun Mo Lee/2Sung Eun Namkoong
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Abstract
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-Abstract-
Despite an aggressive surgical debulking followed by front-line chemotherapy, most
patients with advanced ovarian carcinoma die of drug-resistant disease. Drug resistance
can be overcome in a subset of patients with hematologic malignancies and lymphoma
with high-dose therapy (HDT) and hematopoietic stem cell transplantation, suggesting
that this therapy may also be value in ovarian carcinoma. We report the successful
outcome of HDT and peripheral blood stem cell transplantation (PBSCT) in a
41-year-old nulliparous woman who initially was diagnosed with advanced ovarian
carcicnoma with FIGO stage Ⅲc. Her disease relapsed after 19 months from initial
therapy of definitive surgery and intra-and post-operative chemotherapy. Subsequently,
she received optimal debulking surgery and salvage chemotherapy followed by HDT
with triple-alkylation regimen, composed of cyclophosphamide (100 ㎎/㎏), thiotepa (500
mg/㎡), and melphalan (100㎎/㎡). Her pretranplant characteristics were
platinum-sensitive and complete response state. She showed rapid hematologic recovery
and mild regimen-related toxicity (Bearman's toxicity criteria), stomatitis (grade I),
cardiac toxicity (grade Ⅱ), cardiac toxicity (grade Ⅱ). She has been followed up for 36
months after the inital therapy and is doing well without relapse.
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